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<br /><br /><h1></h1><br />The microscopic examination of the thyroid gave minimal changes follicular hyperplasia , which were statistically not vital between controls and individual dose teams RTF, In vitro research have been performed to evaluate the consequences of resorcinol on thyroid perform. In excessive-dose teams, a lower in body weight and decreased survival were noted. Owing to concern concerning the thyroid results of resorcinol, which have been shown in human studies to occur at excessive doses, this finish-level in particular has been the point of focus in a number of studies. In most of the older studies, the effects of resorcinol publicity on the thyroid gland are conflicting. It has been instructed that thyroid effects seem to be depending on an administration route that allows for continued systemic publicity e.<br />Thyroid glands from all surviving F zero mother and father have been examined microscopically, and brain measurements were performed on all exposed F 1 pups and those F 1 pups chosen for behavioural testing. There have been no significant sex variations. In females, a higher proportion was excreted as sulfate conjugate, whereas males excreted a higher proportion of a diconjugate each sulfate and glucuronide teams. From these data, the authors concluded that male rats have a higher capacity for glucuronidation than females.<br />British Journal of Industrial Medicine , Toxicologic Pathology , Toxicology and Applied Pharmacology , Arnott DG, Doniach I The impact of compounds allied to resorcinol upon the uptake of radioactive iodine I by the thyroid of the rat. IARC evaluated the carcinogenicity of resorcinol in and concluded that there are not any epidemiological knowledge related to the carcinogenicity of resorcinol in humans and that the evidence of its carcinogenicity in animals is inadequate; thus, resorcinol isn't classifiable as to its carcinogenicity to humans. JECFA assessed the hazards from using resorcinol as a meals flavouring agent and concluded that this use is of no security concern. Overall, the research are not sufficient for a statistical extrapolation technique according to the EU Technical Guidance Document EC, a.<br /><br />As is well known in dermal absorption research, the nature of the vehicle has a fantastic affect on the absorption of a compound. Resorcinol appears to be absorbed significantly better from anti-pimples preparations than from the hair dye preparations under regular usage circumstances.<br /><br />The effects had been extra pronounced at 72 h. The irritation index was given as four. However, owing to missing correlating histopathological modifications in the three ranges of the mind examined and in the absence of a dose—response relationship, different indicators of developmental delay, or different modifications in CNS function, these effects were not thought of as conclusive evidence of a change in CNS operate. In the subsequent two-era reproductive toxicity examine RTF, , these end-factors weren't investigated. No resorcinol-related results on F 0 and F 1 pup survival or the final bodily situation of the pups during the pre-weaning period had been observed.<br /><br /><ul><br />  <br />  <br />  <br /> <li>From the scarce information available, the usage of resorcinol in hair dyes zero.</li><br />  <br />  <br />  <br /> <li>In an investigation in three human volunteers using situations much like these used in hair dyeing, 14 C-ring-labelled 1.</li><br />  <br />  <br />  <br /> <li>Five of 3.</li><br />  <br />  <br />  <br /> <li>IARC evaluated the carcinogenicity of resorcinol in and concluded that there are not any epidemiological information relevant to the carcinogenicity of resorcinol in humans and that the proof of its carcinogenicity in animals is inadequate; thus, resorcinol is not classifiable as to its carcinogenicity to humans.</li><br />  <br />  <br />  <br /> <li>There are differences in thyroid physiology between people and animals.</li><br />  <br />  <br />  <br /> <li>In each species, there were no antagonistic results on last imply body weights, haematology, or medical chemistry parameters, and no chemical-related gross or microscopic lesions have been observed.</li><br /> <br /> <br /> <br /></ul><br />Apart from one constructive single case-study Vilaplana et al. In these instances, the examined focus of resorcinol was zero. The data are summarized in Table eight. Data in regards to the totally different job classes weren't offered.<br /><br /><h2></h2><br />Koppers Company studied potential pores and skin irritating results of flaked or industrial resorcinol in male albino rabbits mg beneath occlusive situations over 24 h, scoring after 24 and 72 h. In one examine carried out with male Syrian golden hamsters, which focused solely on results on the forestomach, pyloric region, and urinary bladder, the animals were dosed with zero or 0.<br />In both species, there were no opposed results on final mean body weights, haematology, or medical chemistry parameters, and no chemical-associated gross or microscopic lesions have been observed. In one other examine, rats were uncovered to zero or 0. No thyroid hormone measurements had been performed.<br />From its use in topical medicine and from limited knowledge from occupational studies, resorcinol does not seem like irritating to the pores and skin in the concentrations reported. Van Leeuwen et al. There is not any indication as as to if the teratogenic results had been endocrine mediated or not EC, c. In humans, dermal publicity to resorcinol has been reported to be associated with thyroid results, CNS disturbances, purple blood cell adjustments, and a low incidence of skin sensitization. Five of 3.<br />The acute dermal toxicity of resorcinol was studied in male albino rabbits Koppers Company, Signs of intoxication included salivation, tremors, and convulsions, and handled skin areas showed slight erythema and excessive dryness. Mean information for three donors and sixteen replicates indicate a plateau in receptor fluid focus between 24 and 48 h, as mirrored by cumulative absorption values of 1. A regular-state permeability coefficient. For male albino rats pressure not given;.<br /><br /><h5></h5><br />The third study, carried out in , included of energetic staff. In topics males, 13 women with a mean age of 37 years, both laboratory and different checks, including medical examination, had been accomplished; no irregular thyroid glands or adjustments in T four values have been present in any of the topics when compared with normal values Bauer, The above knowledge are restricted due to small examine sizes, lack of comparability teams, missing present and historic management information, and lacking information concerning potential exposure classes. In a study in a plant producing resorcinol by sulfonation of benzene — and in addition producing beta -resorcylic acid, resorcinol—formaldehyde resins, sulfites, and sulfates — workers had been exposed primarily to resorcinol, however the exposure to other agents was not measured for exposure levels, see section 6. In this plant, three cross-sectional studies had been carried out between and Flickinger, In , medical examinations, chest X-rays, pulmonary function, haematology, and scientific chemistry were carried out with of persons actively employed at a manufacturing plant in Pennsylvania, USA. In addition, male rats have larger circulating levels of TSH than females.
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<br />Complete recovery in all animals occurred within 1—1. Of the next studies, the repeated-dose toxicity research that were deemed to be most relevant to the risk assessment are summarized in Appendix 6. In a research carried out by NTP , 5 female and male F rats were dosed with resorcinol in deionized water via gavage at 0, High-dose females had considerably decreased absolute and relative thymus weights. No other biologically vital differences in organ weights were observed. In distinction to these findings, Eastin et al.<br />In common, the h LC 50 values for resorcinol had been in the vary between In move-by way of exams and analytical monitoring, DeGraeve et al. As mentioned in part 9. Complete healing was noted after about 1 week of absence from work. However, with increasing resorcinol concentrations, there was also a rise within the variety of individuals who examined positive. Resorcinol was also tested in hairdressers, who could have been involved with resorcinol-containing hair dyes.<br /><br /><h2></h2><br />These figures agree nicely with the above exposure estimate based on the Yeung et al.<br />The tolerable consumption of zero. It is due to this fact attainable that these neurological results are because of the acute impact of the gavage administration. CNS results in people and animals have been related to acute exposure to resorcinol.<br /><br />Although thyroid effects are a major end-level in each human case-studies and animal studies, there's a lack of consistency in the ends in the animal studies. Resorcinol triggered no adverse results in several replica and developmental toxicity research in rats and rabbits. Resorcinol just isn't thought of to be genotoxic.<br /><br /><h1></h1><br />The results have been extra pronounced at 72 h. The irritation index was given as 4. However, owing to lacking correlating histopathological adjustments in the three levels of the brain examined and in the absence of a dose—response relationship, different indicators of developmental delay, or different changes in CNS operate, these results were not thought-about as conclusive evidence of a change in CNS function. In the next two-era reproductive toxicity examine RTF, , these finish-factors weren't investigated. No resorcinol-related effects on F 0 and F 1 pup survival or the final physical situation of the pups during the pre-weaning interval had been observed.<br />The third research, performed in , included of energetic employees. In subjects males, thirteen girls with a mean age of 37 years, each laboratory and different checks, including medical examination, had been carried out; no abnormal thyroid glands or adjustments in T 4 values had been found in any of the subjects when compared with normal values Bauer, The above information are limited because of small study sizes, lack of comparability groups, missing current and historical management information, and missing info concerning potential exposure categories. In a examine in a plant producing resorcinol by sulfonation of benzene — and also producing beta -resorcylic acid, resorcinol—formaldehyde resins, sulfites, and sulfates — employees were uncovered primarily to resorcinol, however the exposure to different brokers was not measured for exposure ranges, see section 6. In this plant, three cross-sectional research have been carried out between and Flickinger, In , medical examinations, chest X-rays, pulmonary function, haematology, and clinical chemistry were carried out with of individuals actively employed at a manufacturing plant in Pennsylvania, USA. In addition, male rats have higher circulating levels of TSH than females.<br />In one other study, male F rats had been handled with three intraperitoneal injections of three-methyl-. Based on the examine of Yeung et al.<br />No resorcinol-related macroscopic findings, organ weight, or antagonistic microscopic target organ results had been noticed within the F zero and F 1 parental animals. The F 0 and F 1 females continued to receive the resorcinol all through mating, gestation, and lactation and through the day of euthanasia for study design, see Appendix 7. There have been no F zero and F 1 parental resorcinol-associated deaths or medical findings in the course of the weekly detailed bodily examinations. In controls and the high-dose group, a qualitative histopathological analysis of the brain forebrain, midbrain, and hindbrain was additionally performed for the aforementioned animals RTF, There had been no opposed effects regarding reproductive performance, mortality, and body or organ weights.<br /><br />Hence, an improved biodegradation price ends in decreased dangers for the environment. Regarding the effects of resorcinol on aquatic species, the toxicity knowledge set includes a wide range of species from different trophic ranges. Results from exams with different aquatic species from completely different trophic levels are available for the acute toxicity of resorcinol to aquatic organisms.<br /><br /><h5></h5><br />The acute dermal toxicity of resorcinol was studied in male albino rabbits Koppers Company, Signs of intoxication included salivation, tremors, and convulsions, and treated skin areas showed slight erythema and extreme dryness. Mean data for three donors and sixteen replicates point out a plateau in receptor fluid concentration between 24 and 48 h, as reflected by cumulative absorption values of 1. A regular-state permeability coefficient. For male albino rats strain not given;.<br />The elimination was biphasic, with half-lives of 18—21 min and 8. The 14 C exercise was rapidly distributed in main tissues such as muscles, kidneys, and liver, with out indication of bioaccumulation Merker et al. Any new information being supplied in the middle of the OECD assessment shall be provided to the IPCS in order that an addendum can be ready for consideration.<br />There are variations in thyroid physiology between people and animals. The weight of proof means that rodents are extra delicate to thyroid effects than humans.

Revision as of 01:07, 19 March 2020


Complete recovery in all animals occurred within 1—1. Of the next studies, the repeated-dose toxicity research that were deemed to be most relevant to the risk assessment are summarized in Appendix 6. In a research carried out by NTP , 5 female and male F rats were dosed with resorcinol in deionized water via gavage at 0, High-dose females had considerably decreased absolute and relative thymus weights. No other biologically vital differences in organ weights were observed. In distinction to these findings, Eastin et al.
In common, the h LC 50 values for resorcinol had been in the vary between In move-by way of exams and analytical monitoring, DeGraeve et al. As mentioned in part 9. Complete healing was noted after about 1 week of absence from work. However, with increasing resorcinol concentrations, there was also a rise within the variety of individuals who examined positive. Resorcinol was also tested in hairdressers, who could have been involved with resorcinol-containing hair dyes.


These figures agree nicely with the above exposure estimate based on the Yeung et al.
The tolerable consumption of zero. It is due to this fact attainable that these neurological results are because of the acute impact of the gavage administration. CNS results in people and animals have been related to acute exposure to resorcinol.

Although thyroid effects are a major end-level in each human case-studies and animal studies, there's a lack of consistency in the ends in the animal studies. Resorcinol triggered no adverse results in several replica and developmental toxicity research in rats and rabbits. Resorcinol just isn't thought of to be genotoxic.


The results have been extra pronounced at 72 h. The irritation index was given as 4. However, owing to lacking correlating histopathological adjustments in the three levels of the brain examined and in the absence of a dose—response relationship, different indicators of developmental delay, or different changes in CNS operate, these results were not thought-about as conclusive evidence of a change in CNS function. In the next two-era reproductive toxicity examine RTF, , these finish-factors weren't investigated. No resorcinol-related effects on F 0 and F 1 pup survival or the final physical situation of the pups during the pre-weaning interval had been observed.
The third research, performed in , included of energetic employees. In subjects males, thirteen girls with a mean age of 37 years, each laboratory and different checks, including medical examination, had been carried out; no abnormal thyroid glands or adjustments in T 4 values had been found in any of the subjects when compared with normal values Bauer, The above information are limited because of small study sizes, lack of comparability groups, missing current and historical management information, and missing info concerning potential exposure categories. In a examine in a plant producing resorcinol by sulfonation of benzene — and also producing beta -resorcylic acid, resorcinol—formaldehyde resins, sulfites, and sulfates — employees were uncovered primarily to resorcinol, however the exposure to different brokers was not measured for exposure ranges, see section 6. In this plant, three cross-sectional research have been carried out between and Flickinger, In , medical examinations, chest X-rays, pulmonary function, haematology, and clinical chemistry were carried out with of individuals actively employed at a manufacturing plant in Pennsylvania, USA. In addition, male rats have higher circulating levels of TSH than females.
In one other study, male F rats had been handled with three intraperitoneal injections of three-methyl-. Based on the examine of Yeung et al.
No resorcinol-related macroscopic findings, organ weight, or antagonistic microscopic target organ results had been noticed within the F zero and F 1 parental animals. The F 0 and F 1 females continued to receive the resorcinol all through mating, gestation, and lactation and through the day of euthanasia for study design, see Appendix 7. There have been no F zero and F 1 parental resorcinol-associated deaths or medical findings in the course of the weekly detailed bodily examinations. In controls and the high-dose group, a qualitative histopathological analysis of the brain forebrain, midbrain, and hindbrain was additionally performed for the aforementioned animals RTF, There had been no opposed effects regarding reproductive performance, mortality, and body or organ weights.

Hence, an improved biodegradation price ends in decreased dangers for the environment. Regarding the effects of resorcinol on aquatic species, the toxicity knowledge set includes a wide range of species from different trophic ranges. Results from exams with different aquatic species from completely different trophic levels are available for the acute toxicity of resorcinol to aquatic organisms.


The acute dermal toxicity of resorcinol was studied in male albino rabbits Koppers Company, Signs of intoxication included salivation, tremors, and convulsions, and treated skin areas showed slight erythema and extreme dryness. Mean data for three donors and sixteen replicates point out a plateau in receptor fluid concentration between 24 and 48 h, as reflected by cumulative absorption values of 1. A regular-state permeability coefficient. For male albino rats strain not given;.
The elimination was biphasic, with half-lives of 18—21 min and 8. The 14 C exercise was rapidly distributed in main tissues such as muscles, kidneys, and liver, with out indication of bioaccumulation Merker et al. Any new information being supplied in the middle of the OECD assessment shall be provided to the IPCS in order that an addendum can be ready for consideration.
There are variations in thyroid physiology between people and animals. The weight of proof means that rodents are extra delicate to thyroid effects than humans.