Complete recovery in all animals occurred within 1—1. Of the next studies, the repeated-dose toxicity research that were deemed to be most relevant to the risk assessment are summarized in Appendix 6. In a research carried out by NTP , 5 female and male F rats were dosed with resorcinol in deionized water via gavage at 0, High-dose females had considerably decreased absolute and relative thymus weights. No other biologically vital differences in organ weights were observed. In distinction to these findings, Eastin et al.
In common, the h LC 50 values for resorcinol had been in the vary between In move-by way of exams and analytical monitoring, DeGraeve et al. As mentioned in part 9. Complete healing was noted after about 1 week of absence from work. However, with increasing resorcinol concentrations, there was also a rise within the variety of individuals who examined positive. Resorcinol was also tested in hairdressers, who could have been involved with resorcinol-containing hair dyes.
These figures agree nicely with the above exposure estimate based on the Yeung et al.
The tolerable consumption of zero. It is due to this fact attainable that these neurological results are because of the acute impact of the gavage administration. CNS results in people and animals have been related to acute exposure to resorcinol.
Although thyroid effects are a major end-level in each human case-studies and animal studies, there's a lack of consistency in the ends in the animal studies. Resorcinol triggered no adverse results in several replica and developmental toxicity research in rats and rabbits. Resorcinol just isn't thought of to be genotoxic.
The results have been extra pronounced at 72 h. The irritation index was given as 4. However, owing to lacking correlating histopathological adjustments in the three levels of the brain examined and in the absence of a dose—response relationship, different indicators of developmental delay, or different changes in CNS operate, these results were not thought-about as conclusive evidence of a change in CNS function. In the next two-era reproductive toxicity examine RTF, , these finish-factors weren't investigated. No resorcinol-related effects on F 0 and F 1 pup survival or the final physical situation of the pups during the pre-weaning interval had been observed.
The third research, performed in , included of energetic employees. In subjects males, thirteen girls with a mean age of 37 years, each laboratory and different checks, including medical examination, had been carried out; no abnormal thyroid glands or adjustments in T 4 values had been found in any of the subjects when compared with normal values Bauer, The above information are limited because of small study sizes, lack of comparability groups, missing current and historical management information, and missing info concerning potential exposure categories. In a examine in a plant producing resorcinol by sulfonation of benzene — and also producing beta -resorcylic acid, resorcinol—formaldehyde resins, sulfites, and sulfates — employees were uncovered primarily to resorcinol, however the exposure to different brokers was not measured for exposure ranges, see section 6. In this plant, three cross-sectional research have been carried out between and Flickinger, In , medical examinations, chest X-rays, pulmonary function, haematology, and clinical chemistry were carried out with of individuals actively employed at a manufacturing plant in Pennsylvania, USA. In addition, male rats have higher circulating levels of TSH than females.
In one other study, male F rats had been handled with three intraperitoneal injections of three-methyl-. Based on the examine of Yeung et al.
No resorcinol-related macroscopic findings, organ weight, or antagonistic microscopic target organ results had been noticed within the F zero and F 1 parental animals. The F 0 and F 1 females continued to receive the resorcinol all through mating, gestation, and lactation and through the day of euthanasia for study design, see Appendix 7. There have been no F zero and F 1 parental resorcinol-associated deaths or medical findings in the course of the weekly detailed bodily examinations. In controls and the high-dose group, a qualitative histopathological analysis of the brain forebrain, midbrain, and hindbrain was additionally performed for the aforementioned animals RTF, There had been no opposed effects regarding reproductive performance, mortality, and body or organ weights.
Hence, an improved biodegradation price ends in decreased dangers for the environment. Regarding the effects of resorcinol on aquatic species, the toxicity knowledge set includes a wide range of species from different trophic ranges. Results from exams with different aquatic species from completely different trophic levels are available for the acute toxicity of resorcinol to aquatic organisms.
The acute dermal toxicity of resorcinol was studied in male albino rabbits Koppers Company, Signs of intoxication included salivation, tremors, and convulsions, and treated skin areas showed slight erythema and extreme dryness. Mean data for three donors and sixteen replicates point out a plateau in receptor fluid concentration between 24 and 48 h, as reflected by cumulative absorption values of 1. A regular-state permeability coefficient. For male albino rats strain not given;.
The elimination was biphasic, with half-lives of 18—21 min and 8. The 14 C exercise was rapidly distributed in main tissues such as muscles, kidneys, and liver, with out indication of bioaccumulation Merker et al. Any new information being supplied in the middle of the OECD assessment shall be provided to the IPCS in order that an addendum can be ready for consideration.
There are variations in thyroid physiology between people and animals. The weight of proof means that rodents are extra delicate to thyroid effects than humans.